A father's and physician's wide-ranging thoughts regarding our typical, and not so typical, lives
Even if you don’t like to listen to, or read about finance, economics, banking, or start-up technology companies, please listen to a good chunk of the All-in Podcast regarding this sudden bank collapse. This affects us all, even if you can’t see the reasons.
Charles Tadros, M.D.
March 13, 2023
Saint Louis, Missouri
Cardiovascular and lipid experts don’t talk about this enough… for many years we’ve had several drugs that lower cholesterol or triglycerides but don’t improve morbidity or mortality (heart attacks, coronary artery stents, coronary artery bypass, or stroke numbers).
Statins lower LDL cholesterol and raise HDL cholesterol and show improvements in cardiovascular morbidity and mortality.
This is a statement from the product insert for bempedoic acid:
INDICATION AND IMPORTANT SAFETY INFORMATION
INDICATION
NEXLETOL and NEXLIZET are indicated as adjuncts to diet and maximally tolerated statin therapy for the treatment of adults with heterozygous familial hypercholesterolemia or established atherosclerotic cardiovascular disease who require additional lowering of LDL-C.
Limitations of Use:
The effect of NEXLETOL and NEXLIZET on cardiovascular morbidity and mortality has not been determined
So if a drug manufacturer added a new cholesterol lowering compound to some small level of tolerable statin, then if researchers ever see any positive effects on morbidity or mortality, some of it may be from the statin.
You can see that they have another drug , Zetia/ ezetimibe, which is combined with the new bempedoic acid (Nexlizit).
Well, it turns out that the Zetia is also an add-on drug to statins. Zetia was introduced 20 years ago, also for people who don’t tolerate statins.
Zetia, by itself, does not reduce cardiovascular morbidity or mortality.
Zetia has been cheap for years because it’s a generic… generic drug plus a new, name brand drug, equals a very expensive, combination, pill.
I am very eager to see improvements in morbidity and mortality numbers for this new bempedoic acid.
Charles Tadros, MD
March 6, 2023
Saint Louis, Missouri
https://www.instagram.com/reel/CmJ9Ea_JrpP/?igshid=MDJmNzVkMjY=
Charles Tadros, M.D.
February 25, 2023
Saint Louis, Missouri
I grew up with my parents and my brothers around me all the time. There was love. At times that love revolved around right words and right actions, with occasional harsh corrections.
The older I get, and the more adolescents and adults that I see for their mental health concerns, the more I recognize that kids need loving, stable, boundaries. They need to learn by frequent, excellent examples…by witnessing how things are said, what things are said, how things are done, how people behave, and how to treat each other.
Kids are exceptionally good imitators. They want to do good work. They want to show-off their good work and accomplishments. They want to become independent, competent, and confident. They want to be complimented. They want and need your attention and your encouragement.
In contrast, corrections, reprimands, demerits, tongue lashings, public or private shaming, corporal punishment, and corrective action plans are demoralizing, and at their worst, work temporarily, create traumatic defensive behaviors, and are dehumanizing.
Charles Tadros, M.D.
February 24, 2023
Saint Louis, Missouri
we won’t or don’t question some of our own basic assumptions. We, willingly, continue down decision paths or pursue actions, many of which are absolutely ridiculous, even if we recognize our foolishness. In the face of all these contradictions, we still do not, or will not, stop, change course, or ask for help.
Charles Tadros, M.D.
February 11, 2023
Saint Louis, Missouri
Evenness of mind especially under stress (merriam-webster.com)
If you think “equanimity” looks like it has something to do with “equal,” you’ve guessed correctly. Both “equanimity” and “equal” are derived from “aequus,” a Latin adjective meaning “level” or “equal.” “Equanimity” comes from the combination of “aequus” and “animus” (“soul” or “mind”) in the Latin phrase aequo animo, which means “with even mind.” English speakers began using “equanimity” early in the 17th century with the now obsolete sense “fairness or justness of judgment,” which was in keeping with the meaning of the Latin phrase. Equanimity quickly came to suggest keeping a cool head under any sort of pressure, not merely when presented with a problem, and eventually, it developed an extended sense for general balance and harmony.(merriam-webster.com)
Charles Tadros M.D.
February 8, 2023
Saint Louis, Missouri
The vast majority of us have credit card debt, home loan debt, automobile loan debt, school loan debt, medical bill-related debt, gambling debt, investment margin debt, business-related debt, liens against our property, or owe money to a friend or relative. Too often, these debts last long after the joy and usefulness of the product or service has left us.
Charles Tadros, M.D.
February 7, 2023
Saint Louis, Missouri
Charles Tadros, M.D.
February 7, 2023
Saint Louis, Missouri
We may not have absolute free-will. It may be that certain biological forces sway our thoughts, perceptions, decisions, and actions much more than we realize.
Charles Tadros, M.D.
February 4, 2023
Saint Louis, Missouri
Too often the subjects of our training and education are not necessarily what we are good at performing, nor do they give us joy. Even if our training, education, performing, and joy all align, such qualities do not necessarily, or automatically, translate into a good income, financial stability, or help us to become wealthy.
Very often, what we selected when we were 18 years-old is a single, narrow, training or educational path beyond high school. This may excessively narrow our exposure to lucrative opportunities, to fruitful connections, or to enriching environments. In turn, these lost opportunities may excessively narrow our visions and our choices of career paths.
Charles Tadros, M.D.
February 1, 2023
Saint Louis, Missouri